Semax Dosagem: 1mg SubQ, 2-3x/Week Protocol (2026)

1mg twice weekly is reported to hit the BDNF sweet spot without overdriving it. Covers SubQ protocol, 8-week cycling, and Selank stacking.

Semax is a synthetic heptapeptide analog of ACTH(4-10) — the fragment of adrenocorticotropic hormone responsible for cognitive effects without hormonal activity. Approved in Russia for cognitive disorders and ischemic stroke, it has documented BDNF upregulation and neuroprotective effects.

Research-context information only. Semax is a research peptide. Protocols, doses, and reactions reported below come from published research and self-reported community sources. This article reports what has been documented, not what should be done. Consult a licensed physician for personal medical decisions.

Semax is not FDA-approved. It has clinical approval in Russia only. This is not medical advice. For a deeper look at how Semax works, see our Semax benefits guide .

Semax Dosing Table

Match your vial size below — reconstitution and dose math update automatically.

Math assumes U-100 insulin syringes (1 mL = 100 units). Verify your syringe matches before injecting. Round half-units to the nearest visible mark.

Math assumes U-100 insulin syringes (1 mL = 100 units). Verify your syringe matches before injecting. Round half-units to the nearest visible mark.

Math assumes U-100 insulin syringes (1 mL = 100 units). Verify your syringe matches before injecting. Round half-units to the nearest visible mark.

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Quick Reference: Standard Protocol

For stack protocols and peptide comparisons, see our peptide stacking guide .

Cycling Details

The standard cycle is 1 mg subcutaneous in the morning, 2-3 days per week, for 8 weeks on / 8 weeks off.

Weeks 1-2 (Assessment): Documented protocols begin at 1 mg, 2 days per week, to gauge cognitive response and tolerance. Semax has mild stimulatory effects — community sources describe dosing before cognitive tasks and avoiding late evening dosing.

Weeks 3-8 (Maintenance): Continue at 1 mg, 2-3 days per week based on response. Community sources commonly describe residual cognitive benefits persisting into the off-cycle.

Semax Variants

• Standard Semax — the original clinically studied heptapeptide
• N-Acetyl Semax (NASA) — acetylated for improved stability and CNS penetration
• N-Acetyl Semax Amidate — further modified for enhanced potency; less clinical data

Routes of Administration

Intranasal spray is the original Russian clinical route. Clinical protocols used 0.1% and 1% solutions. Effects reported within 15-30 minutes of nasal delivery.

Subcutaneous injection is the community alternative, offering more consistent absorption. Standard sites: abdomen, love handles. Use 29-31 gauge insulin syringe.

Reconstitution Quick Reference

Math: 30 mg / 3 mL = 10 mg/mL. For 1 mg: 1 / 10 = 0.1 mL = 10 units.

Community protocols describe gentle swirling — not shaking — to avoid degradation, with storage at 2–8°C and use within 28 days.

Where These Numbers Come From

Semax has a substantial clinical evidence base from Russian research institutions.

Dopaminergic and serotonergic activation: Semax activates brain dopamine and serotonin systems, explaining its nootropic and mood-enhancing effects ( Eremin et al., 2005 ).

BDNF upregulation: A single intranasal dose increases BDNF protein levels 1.4-fold and BDNF mRNA 3-fold in the rat hippocampus, with concurrent trkB receptor activation ( Dolotov et al., 2006 ).

Stroke neuroprotection: Clinical evaluation as a neuroprotective agent in acute ischemic stroke at 100-150 mcg/kg doses, with angioprotective and neurotrophic activity ( Gusev et al., 1999 ). Semax suppresses proinflammatory mediator transcription during brain ischemia ( Dergunova et al., 2021 ).

Stacking Protocols

Overstimulation is reported when Semax is combined with caffeine or other stimulants. Community sources describe keeping stimulating stacks to the first half of the day.

Side Effects & Safety

• Low toxicity — extensive preclinical and clinical testing in Russia
• No hormonal effects — unlike full ACTH, Semax does not stimulate cortisol or adrenal activity
• No tolerance documented — Russian clinical trial data report consistent efficacy across documented course durations
• Mild nasal irritation — intranasal route
• Slight headache — particularly first 1-2 days
• Mild insomnia — if dosed too late in the day
• Hair loss — community sources describe rare reports at elevated doses, speculatively attributed to melanocortin receptor activity
• Clinical exclusion criteria (from Russian trial protocols): Pregnancy/breastfeeding, active malignancy (BDNF/growth-factor interactions noted), acute psychosis (dopaminergic stimulation). Trial protocols excluded subjects with these profiles.

mg to Units Conversion

On a standard 100-unit insulin syringe, each "unit" equals 0.01 mL (so 100 units = 1 mL). Once Semax is reconstituted, the conversion from a target dose to syringe units depends on the chosen dilution.

The two reconstitution ratios most often described in community protocols are below.

Reconstitution A: 30 mg vial + 3 mL BAC water (10 mg/mL) — the standard dilution from the Quick Reference above.

Reconstitution B: 30 mg vial + 5 mL BAC water (6 mg/mL) — more BAC water for larger, easier-to-measure draws.

These conversions reflect the dilutions documented in community reconstitution protocols. They report how the math is described, not a recommended dosing schedule.

Frequently Asked Questions

Related Guides

• Semax Side Effects: Russian Trial Data — adverse event profile from clinical trials and community reports
• Semax Benefits — 7 cognitive effects ranked by evidence quality
• Semax Results Timeline — Week-by-week expectations
• Selank vs Semax — Which nootropic peptide fits your goals
• Selank Dosing Guide — Anxiolytic peptide for stacking
• DSIP Dosing Guide — Sleep peptide for cognitive recovery
• BPC-157 Dosing Guide — Neuroprotective and gut-brain axis support
• SS-31 Dosing Guide — Mitochondrial peptide for brain energy
• Peptide Stacking Guide — Principles for combining Semax with other peptides
• Calculate Your Semax Cycle Cost — estimate vials needed and total cost for your protocol
• Semax Buying Guide — Russian peptide sourcing + COA red flags
• Semax/Selank Buying Guide — nootropic blend pricing + COA standards

References

For educational and research purposes only. This is not medical advice. Semax has clinical approval in Russia but is not FDA-approved.

Tabelas de referência

Perguntas frequentes

What is the standard Semax dose?

Documented protocols describe 1 mg subcutaneously in the morning, 2-3 days per week, cycled 8 weeks on / 8 weeks off. Protocols describe reconstituting a 30 mg vial with 3 mL BAC water (10 mg/mL) and drawing 10 units per dose.

How long does Semax take to work?

Community sources report cognitive effects within 15-30 minutes of intranasal administration. BDNF-related neuroplasticity effects are documented in Russian trial subjects over days to weeks of consistent dosing.

What is the difference between Semax and N-Acetyl Semax?

N-Acetyl Semax (NASA) has improved stability and CNS penetration. N-Acetyl Semax Amidate is further modified for enhanced potency. Standard Semax has the most clinical data.

How long should a Semax cycle last?

Community protocols document 8 weeks on / 8 weeks off. This structure is described in community sources as supporting receptor sensitivity, with limited long-term clinical data available.

Can Semax be used for stroke recovery?

Semax is approved in Russia for ischemic stroke treatment with clinical trial data supporting neuroprotective effects. It is NOT FDA-approved and should not replace standard stroke care.

What does research report about daily Semax use?

Russian clinical data supports short-term daily use (10-30 days). Most community protocols use cycling as a conservative approach given limited long-term data.